BP302T. PHYSICAL
PHARMACEUTICS-I (Theory) 45Hours
Scope: The course deals
with the various physica and physicochemical properties, and
principles involved in dosage
forms/formulations. Theory and practical
components of the subject help
the student to get a better insight into various
areas of formulation research and
development, and stability studies of
pharmaceutical dosage forms.
Objectives: Upon the
completion of the course student shall be able to
1. Understand various
physicochemical properties of drug molecules in the
designing the dosage forms
2. Know the principles of
chemical kinetics & to use them for stability testing nad
determination of expiry date of
formulations
3. Demonstrate use of
physicochemical properties in the formulation
development and evaluation of
dosage forms.
Course Content:
UNIT-I 10 Hours
Solubility of
drugs: Solubility
expressions, mechanisms of solute solvent interactions,
ideal solubility parameters,
solvation & association, quantitative approach to the factors
influencing solubility of drugs,
diffusion principles in biological systems. Solubility
of gas in liquids, solubility of
liquids in liquids, (Binary solutions, ideal solutions)
Raoult’s law, real solutions.
Partiallymiscible liquids, Critical solution temperature and
applications. Distribution law,
its limitations and applications
UNIT-II 10Hours
States of Matter
and
properties of matter:State of matter, changes in the state of
matter,
latent heats, vapour pressure,
sublimation critical point, eutectic mixtures, gases, aerosols
– inhalers, relative humidity,
liquid complexes, liquid crystals, glassy states, solidcrystalline,
amorphous & polymorphism.
Physicochemical
properties of drug molecules: Refractive index, optical rotation,
dielectric constant, dipole
moment, dissociation constant, determinations and applications
UNIT-III 08
Hours
Surface and interfacial
phenomenon: Liquid
interface, surface & interfacial tensions,
surface free energy, measurement
of surface & interfacial tensions, spreading coefficient,
adsorption at liquid interfaces,
surface active agents, HLB Scale, solubilisation,
detergency, adsorption at solid
interface.
76
UNIT-IV 08Hours
Complexation and
protein binding: Introduction,
Classification of Complexation,
Applications, methods of
analysis, protein binding, Complexation and drug action,
crystalline structures of
complexes and thermodynamic treatment of stability constants.
UNIT-V 07 Hours
pH, buffers and
Isotonic solutions: Sorensen’s
pH scale, pH determination
(electrometric and calorimetric),
applications of buffers, buffer equation, buffer capacity,
buffers in pharmaceutical and
biological systems, buffered isotonic solutions.
BP306P. PHYSICAL
PHARMACEUTICS – I (Practical)
4 Hrs/week
1. Determination
the solubility of drug at room temperature
2. Determination
of pKa value by Half Neutralization/ Henderson Hasselbalch equation.
3. Determination
of Partition co- efficient of benzoic acid in benzene and water
4. Determination
of Partition co- efficient of Iodine in CCl4 and
water
5. Determination
of % composition of NaCl in a solution using phenol-water system by
CST method
6. Determination
of surface tension of given liquids by drop count and drop weight method
7. Determination
of HLB number of a surfactant by saponification method
8. Determination
of Freundlich and Langmuir constants using activated char coal
9. Determination
of critical micellar concentration of surfactants
10.
Determination of stability constant and donor acceptor ratio of PABA-Caffeine complex
by solubility method
11.
Determination of stability constant and donor acceptor ratio of Cupric-Glycine complex
by pH titration method
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