BP 403 T.
PHYSICAL PHARMACEUTICS-II (Theory) 45Hours
Scope: The course deals
with the various physica and physicochemical properties, and
principles involved in dosage
forms/formulations. Theory and practical
components of the subject help
the student to get a better insight into various
areas of formulation research and
development, and stability studies of
pharmaceutical dosage forms.
Objectives: Upon the
completion of the course student shall be able to
1. Understand various physicochemical
properties of drug molecules in the
designing the dosage forms
2. Know the principles of
chemical kinetics & to use them for stability testing nad
determination of expiry date of
formulations
3. Demonstrate use of physicochemical
properties in the formulation
development and evaluation of
dosage forms.
Course Content:
UNIT-I 07
Hours
Colloidal
dispersions: Classification
of dispersed systems & their general
characteristics, size &
shapes of colloidal particles, classification of colloids &
comparative account of their
general properties. Optical, kinetic & electrical properties.
Effect of electrolytes,
coacervation, peptization& protective action.
UNIT-II 10
Hours
Rheology: Newtonian
systems, law of flow, kinematic viscosity, effect of temperature,
non-Newtonian systems,
pseudoplastic, dilatant, plastic, thixotropy, thixotropy in
formulation, determination of
viscosity, capillary, falling Sphere, rotational viscometers
Deformation of
solids: Plastic
and elastic deformation, Heckel equation, Stress, Strain,
Elastic Modulus
UNIT-III 10
Hours
Coarse
dispersion: Suspension,
interfacial properties of suspended particles, settling in
suspensions, formulation of
flocculated and deflocculated suspensions. Emulsions and
theories of emulsification,
microemulsion and multiple emulsions; Stability of emulsions,
preservation of emulsions,
rheological properties of emulsions and emulsion
formulation by HLB method.
95
UNIT-IV 10Hours
Micromeretics: Particle size
and distribution, mean particle size, number and weight
distribution, particle number,
methods for determining particle size by different
methods, counting and separation
method, particle shape, specific surface, methods for
determining surface area,
permeability, adsorption, derived properties of powders,
porosity, packing arrangement,
densities, bulkiness & flow properties.
UNIT-V 10 Hours
Drug stability: Reaction
kinetics: zero, pseudo-zero, first & second order, units of basic
rate constants, determination of
reaction order. Physical and chemical factors influencing
the chemical degradation of
pharmaceutical product: temperature, solvent, ionic strength,
dielectric constant, specific
& general acid base catalysis, Simple numerical problems.
Stabilization of medicinal agents
against common reactions like hydrolysis & oxidation.
Accelerated stability testing in
expiration dating of pharmaceutical dosage forms.
Photolytic degradation and its
prevention
BP 407P.
PHYSICAL PHARMACEUTICS- II (Practical)
3 Hrs/week
1. Determination of particle size,
particle size distribution using sieving method
2. Determination of particle size,
particle size distribution using Microscopic method
3. Determination of bulk density, true
density and porosity
4. Determine the angle of repose and influence
of lubricant on angle of repose
5. Determination of viscosity of liquid
using Ostwald’s viscometer
6. Determination sedimentation volume
with effect of different suspending agent
7. Determination sedimentation volume
with effect of different concentration of
single suspending agent
8. Determination of viscosity of
semisolid by using Brookfield viscometer
9. Determination of reaction rate
constant first order.
10. Determination of reaction rate
constant second order
11. Accelerated stability studies
